pentobarbital will reduce the extent or influence of darunavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will decrease the extent or effect of oliceridine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. If coadministration using a CYP3A4 inducer is critical, con